My favorite golf hole ever played is the 17th on the Old Course at St. Andrews in Scotland. Commonly referred to as The Road Hole, it combines unique quirkiness with an ever-challenging yet playable design.
I would not consider it a “natural hole” due to the railroad barn/hotel and stone wall and road elements to contend with, all of which are not made by Mother Nature. Although it fits the environment and ambiance of the legendary links perfectly and adds to the experience immensely.
Playing the hole well requires courage, wisdom, and skill. The drive is of a risk-reward nature where you drive it blindly, more right the more courage and the more risk/reward. The second to a back left flag could be one of the most daunting shots with the famous road hole bunker directly in play. All that coupled with firm playing surfaces, a stiff breeze, and a stone wall ruled as an integral part of the course and I consider it the best hole in golf as well as my favorite.